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Dr Rebecca Charlton

Staff details

PositionSenior Lecturer in Psychology
Department Psychology
Email r.charlton (@gold.ac.uk)
Phone+44 (0)20 7919 7222
Dr Rebecca Charlton

Summary of research

  • Ageing and age-related disorders;
  • The effect of vascular damage in the brain on cognition and mood;
  • Depression across the lifespan;
  • Neuroimaging;
  • Ageing in developmental disorders including Autism Spectrum Disorder.

Academic qualifications

BSc MSc PhD

Teaching

BSc Psychology

PS52001A: Biological Substrates of Behaviour

PS52007A: Research Methods in Psychology

MSc Cognitive & Clinical Neuroscience

PS71045A: Research Project

Areas of supervision

  • Ageing and age-related disorders
  • Late-life depression / Subclinical low mood in older adults
  • Ageing in Developmental Disorders
  • Stroke and Vascular Dementia
  • Depression
  • Associations between ill-health and cognition

Research Interests

My research combines cognitive and neuroimaging methods to answer questions about brain-behaviour associations. My main focus is in age-related conditions and falls into three areas.

Typical Ageing: I examine associations between cognitive decline and changes in the brain with particular reference to cognitive networks and white matter/vascular damage. I am also interested in exploring low mood among older adults and how low mood interacts with cognitive changes in ageing. 

Depression: I use MRI to examine the mechanisms for developing late-life depression and risk for associated cognitive deficits. I am currently working on a project to elevate mood among older adults.

Ageing in Developmental Disorders: Little is known about how individuals with Autism Spectrum Disorders will be affected by age-related brain, cognitive or social changes, I am interested in exploring ageing across developmental disorders.

Publications

Article

Mnemonic function in small vessel disease and associations with white matter tract microstructure
Metoki, A; Brookes, R.L.; Zeestraten, E.; Lawrence, A.J.; Morris, R.G.; Barrick, Thomas R; Markus, Hugh S and Charlton, Rebecca A. 2017. Mnemonic function in small vessel disease and associations with white matter tract microstructure. Neuropsychologia, 104, pp. 1-7. ISSN 0028-3932

Divergent Influences of Cardiovascular Disease Risk Factor Domains on Cognition, Grey and White Matter Morphology
Gonzales, M.M.; Ajilore, Olusola; Charlton, Rebecca A; Cohen, J.; Yang, Shaolin; Sieg, E.; Bhaumik, Dulal K.; Kumar, Anand and Lamar, Melissa. 2017. Divergent Influences of Cardiovascular Disease Risk Factor Domains on Cognition, Grey and White Matter Morphology. Psychosomatic Medicine, 79(5), pp. 541-548. ISSN 0033-3174

Demographic and cognitive profile of individuals seeking a diagnosis of Autism Spectrum Disorder in adulthood
Happé, Francesca G.E.; Mansour, Hassan; Barrett, Pippa; Brown, Tony; Abbott, Patricia and Charlton, Rebecca A. 2016. Demographic and cognitive profile of individuals seeking a diagnosis of Autism Spectrum Disorder in adulthood. Journal of Autism and Developmental Disorders, 46(11), pp. 3469-3480. ISSN 0162-3257

Cognitive and connectome properties detectable through individual differences in graphomotor organization
Lamar, Melissa; Ajilore, Olusola; Leow, Alex; Charlton, Rebecca A; Cohen, Jamie; GadElkarim, Johnson; Yang, Shaolin; Zhang, Aifeng; Davis, Randall; Penney, Dana; Libon, David J and Kumar, Anand. 2016. Cognitive and connectome properties detectable through individual differences in graphomotor organization. Neuropsychologia, 85, pp. 301-309. ISSN 0028-3932

Aging and Autism Spectrum Disorder: Evidence from the Broad Autism Phenotype
Wallace, Gregory L.; Budgett, Jessica and Charlton, Rebecca A. 2016. Aging and Autism Spectrum Disorder: Evidence from the Broad Autism Phenotype. Autism Research, ISSN 1939-3792

Brain Connectivity in Late-Life Depression and Aging Revealed by Network Analysis
Charlton, Rebecca A; Leow, Alex; GadElkarim, Johnson; Zhang, Aifeng; Ajilore, Olusola; Yang, Shaolin; Lamar, Melissa and Kumar, Anand. 2015. Brain Connectivity in Late-Life Depression and Aging Revealed by Network Analysis. American Journal of Geriatric Psychiatry, 23(6), pp. 642-650. ISSN 1064-7481

What metabolic syndrome contributes to brain outcomes in African Americans and Caucasian cohorts
Lamar, Melissa; Rubin, Leah; Ajilore, Olusola; Charlton, Rebecca A; Zhang, Aifeng; Yang, Shaolin; Cohen, Jamie and Kumar, Anand. 2015. What metabolic syndrome contributes to brain outcomes in African Americans and Caucasian cohorts. Current Alzheimer Research, 12(7), pp. 640-647. ISSN 1567-2050

Associations between vascular risk and mood in euthymic older adults: Preliminary findings
Charlton, Rebecca A. 2014. Associations between vascular risk and mood in euthymic older adults: Preliminary findings. American Journal of Geriatric Psychiatry, 22(9), pp. 936-945. ISSN 1064-7481

Subcortical Biophysical Abnormalities in Patients with Mood Disorders
Charlton, Rebecca A. 2014. Subcortical Biophysical Abnormalities in Patients with Mood Disorders. Molecular Psychiatry, 19, pp. 710-716. ISSN 1359-4184

White Matter Tract Integrity in Late-Life Depression: Associations with Severity and Cognition
Charlton, Rebecca A. 2014. White Matter Tract Integrity in Late-Life Depression: Associations with Severity and Cognition. Psychological Medicine, 44(7), pp. 1427-1437. ISSN 0033-2917

In Vivo Quantification of White Matter Microstructure for Use in Aging: A Focus on Two Emerging Techniques
Charlton, Rebecca A. 2014. In Vivo Quantification of White Matter Microstructure for Use in Aging: A Focus on Two Emerging Techniques. American Journal of Geriatric Psychiatry, 22(2), pp. 111-121. ISSN 1064-7481

Verbal working and long-term episodic memory associations with white matter microstructure in normal aging investigated using tract-based spatial statistics
Charlton, Rebecca A. 2013. Verbal working and long-term episodic memory associations with white matter microstructure in normal aging investigated using tract-based spatial statistics. Psychology and Aging, 28(3), pp. 768-777. ISSN 0882-7974

Prefrontal vulnerabilities and whole brain connectivity in aging and depression.
Lamar, Melissa; Charlton, Rebecca A; Ajilore, Olusola; Zhang, Aifeng; Yang, Shaolin; Barrick, Thomas R; Rhodes, Emma and Kumar, Anand. 2013. Prefrontal vulnerabilities and whole brain connectivity in aging and depression. Neuropsychologia, pp. 1-6. ISSN 1873-3514

Preliminary analysis of age of illness onset effects on symptom profiles in major depressive disorder.
Charlton, Rebecca A; Lamar, Melissa; Ajilore, Olusola and Kumar, Anand. 2013. Preliminary analysis of age of illness onset effects on symptom profiles in major depressive disorder. International journal of geriatric psychiatry, pp. 1-9. ISSN 1099-1166

Cognitive Dysfunction in Patients Hospitalized with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD).
Dodd, James W; Charlton, Rebecca A; van den Broek, Martin D and Jones, Paul W. 2013. Cognitive Dysfunction in Patients Hospitalized with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Chest, pp. 1-8. ISSN 1931-3543

Brain structure and function in chronic obstructive pulmonary disease: a multimodal cranial magnetic resonance imaging study.
Dodd, James W; Chung, Ai Wern; van den Broek, Martin D; Barrick, Thomas R; Charlton, Rebecca A and Jones, Paul W. 2012. Brain structure and function in chronic obstructive pulmonary disease: a multimodal cranial magnetic resonance imaging study. American journal of respiratory and critical care medicine, 186(3), pp. 240-5. ISSN 1535-4970

Differential associations between types of verbal memory and prefrontal brain structure in healthy aging and late life depression.
Lamar, Melissa; Charlton, Rebecca A; Zhang, Aifeng and Kumar, Anand. 2012. Differential associations between types of verbal memory and prefrontal brain structure in healthy aging and late life depression. Neuropsychologia, 50(8), pp. 1823-9. ISSN 1873-3514

Aging in autism spectrum disorders: a mini-review.
Happé, Francesca and Charlton, Rebecca A. 2012. Aging in autism spectrum disorders: a mini-review. Gerontology, 58(1), pp. 70-8. ISSN 1423-0003

Brain atrophy and cerebral small vessel disease: a prospective follow-up study.
Nitkunan, Arani; Lanfranconi, Silvia; Charlton, Rebecca A; Barrick, Thomas R and Markus, Hugh S. 2011. Brain atrophy and cerebral small vessel disease: a prospective follow-up study. Stroke; a journal of cerebral circulation, 42(1), pp. 133-8. ISSN 1524-4628

Age differences in FMRI adaptation for sound identity and location.
Grady, Cheryl L; Charlton, Rebecca A; He, Yu and Alain, Claude. 2011. Age differences in FMRI adaptation for sound identity and location. Frontiers in human neuroscience, 5, p. 24. ISSN 1662-5161

The impact of subcortical white matter disease on mood in euthymic older adults: a diffusion tensor imaging study.
Lamar, Melissa; Charlton, Rebecca A; Morris, Robin G and Markus, Hugh S. 2010. The impact of subcortical white matter disease on mood in euthymic older adults: a diffusion tensor imaging study. The American Journal of Geriatric Psychiatry, 18(7), pp. 634-42. ISSN 1545-7214

White matter structural decline in normal ageing: a prospective longitudinal study using tract-based spatial statistics.
Barrick, Thomas R; Charlton, Rebecca A; Clark, Chris A and Markus, Hugh S. 2010. White matter structural decline in normal ageing: a prospective longitudinal study using tract-based spatial statistics. NeuroImage, 51(2), pp. 565-77. ISSN 1053-8119

White matter pathways associated with working memory in normal aging.
Charlton, Rebecca A; Barrick, Thomas R; Lawes, I Nigel C; Markus, Hugh S and Morris, Robin G. 2010. White matter pathways associated with working memory in normal aging. Cortex, 46(4), pp. 474-89. ISSN 1973-8102

The relationship between episodic long-term memory and white matter integrity in normal aging.
Charlton, Rebecca A; Barrick, T R; Markus, H S and Morris, R G. 2010. The relationship between episodic long-term memory and white matter integrity in normal aging. Neuropsychologia, 48(1), pp. 114-22. ISSN 1873-3514

Diffusion tensor imaging detects age related white matter change over a 2 year follow-up which is associated with working memory decline.
Charlton, Rebecca A; Schiavone, F; Barrick, T R; Morris, R G and Markus, H S. 2010. Diffusion tensor imaging detects age related white matter change over a 2 year follow-up which is associated with working memory decline. Journal of Neurology, Neurosurgery, and Psychiatry, 81(1), pp. 13-19. ISSN 0022-3050

Theory of mind associations with other cognitive functions and brain imaging in normal aging.
Charlton, Rebecca A; Barrick, Thomas R; Markus, Hugh S and Morris, Robin G. 2009. Theory of mind associations with other cognitive functions and brain imaging in normal aging. Psychology and aging, 24(2), pp. 338-48. ISSN 0882-7974

Cognitive impairment and white matter damage in hypertension: a pilot study.
Hannesdottir, K; Nitkunan, A; Charlton, Rebecca A; Barrick, T R; MacGregor, G A and Markus, H S. 2009. Cognitive impairment and white matter damage in hypertension: a pilot study. Acta neurologica Scandinavica, 119(4), pp. 261-8. ISSN 1600-0404

Reduced N-acetylaspartate is consistent with axonal dysfunction in cerebral small vessel disease.
Nitkunan, Arani; Charlton, Rebecca A; Barrick, Thomas R; McIntyre, Dominick J O; Howe, Franklyn A and Markus, Hugh S. 2009. Reduced N-acetylaspartate is consistent with axonal dysfunction in cerebral small vessel disease. NMR in biomedicine, 22(3), pp. 285-91. ISSN 0952-3480

Imaging age-related cognitive decline: A comparison of diffusion tensor and magnetization transfer MRI.
Schiavone, Francesca; Charlton, Rebecca A; Barrick, Thomas Richard; Morris, Robin Guy and Markus, Hugh Stephen. 2009. Imaging age-related cognitive decline: A comparison of diffusion tensor and magnetization transfer MRI. Journal of magnetic resonance imaging : JMRI, 29(1), pp. 23-30. ISSN 1053-1807

A structural equation modeling investigation of age-related variance in executive function and DTI measured white matter damage.
Charlton, Rebecca A; Landau, S; Schiavone, F; Barrick, T R; Clark, C A; Markus, H S and Morris, R G. 2008. A structural equation modeling investigation of age-related variance in executive function and DTI measured white matter damage. Neurobiology of aging, 29(10), pp. 1547-55. ISSN 1558-1497

Multimodal MRI in cerebral small vessel disease: its relationship with cognition and sensitivity to change over time.
Nitkunan, Arani; Barrick, Tom R; Charlton, Rebecca A; Clark, Chris A and Markus, Hugh S. 2008. Multimodal MRI in cerebral small vessel disease: its relationship with cognition and sensitivity to change over time. Stroke; a journal of cerebral circulation, 39(7), pp. 1999-2005. ISSN 1524-4628

Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease.
Nitkunan, Arani; Charlton, Rebecca A; McIntyre, Dominick J O; Barrick, Thomas R; Howe, Franklyn A and Markus, Hugh S. 2008. Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 59(3), pp. 528-34. ISSN 0740-3194

Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain.
McIntyre, Dominick J O; Charlton, Rebecca A; Markus, Hugh S and Howe, Franklyn A. 2007. Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain. Journal of magnetic resonance imaging : JMRI, 26(6), pp. 1596-606. ISSN 1053-1807

The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study.
Charlton, Rebecca A; McIntyre, D J O; Howe, F A; Morris, R G and Markus, H S. 2007. The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study. Brain research, 1164, pp. 108-16. ISSN 0006-8993

Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages.
Happé, Francesca; Booth, Rhonda; Charlton, Rebecca A and Hughes, Claire. 2006. Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages. Brain and cognition, 61(1), pp. 25-39. ISSN 0278-2626

The cognitive profiles of CADASIL and sporadic small vessel disease.
Charlton, Rebecca A; Morris, R G; Nitkunan, A and Markus, H S. 2006. The cognitive profiles of CADASIL and sporadic small vessel disease. Neurology, 66(10), pp. 1523-6. ISSN 1526-632X

White matter damage on diffusion tensor imaging correlates with age-related cognitive decline.
Charlton, Rebecca A; Barrick, T R; McIntyre, D J; Shen, Y; O'Sullivan, M; Howe, F A; Clark, C A; Morris, R G and Markus, H S. 2006. White matter damage on diffusion tensor imaging correlates with age-related cognitive decline. Neurology, 66(2), pp. 217-22. ISSN 1526-632X

Diffusion tensor imaging of thalamus correlates with cognition in CADASIL without dementia.
O'Sullivan, Michael; Singhal, Sumeet; Charlton, Rebecca A and Markus, Hugh S. 2004. Diffusion tensor imaging of thalamus correlates with cognition in CADASIL without dementia. Neurology, 62(5), pp. 702-7. ISSN 1526-632X

Disentangling weak coherence and executive dysfunction: planning drawing in autism and attention-deficit/hyperactivity disorder.
Booth, Rhonda; Charlton, Rebecca A; Hughes, Claire and Happé, Francesca. 2003. Disentangling weak coherence and executive dysfunction: planning drawing in autism and attention-deficit/hyperactivity disorder. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 358(1430), pp. 387-92. ISSN 0962-8436

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