Dr Rebecca Charlton

Staff details

PositionSenior Lecturer in Psychology
Department Psychology
Email r.charlton (@gold.ac.uk)
Phone+44 (0)20 7919 7222
Dr Rebecca Charlton

Summary of research

  • Ageing and age-related disorders;
  • The effect of vascular damage in the brain on cognition and mood;
  • Depression across the lifespan;
  • Neuroimaging;
  • Ageing in developmental disorders including Autism Spectrum Disorder.

Academic qualifications

BSc MSc PhD

Teaching

BSc Psychology

PS52001A: Biological Substrates of Behaviour

PS52007A: Research Methods in Psychology

MSc Cognitive & Clinical Neuroscience

PS71045A: Research Project

Areas of supervision

  • Ageing and age-related disorders
  • Late-life depression / Subclinical low mood in older adults
  • Ageing in Developmental Disorders
  • Stroke and Vascular Dementia
  • Depression
  • Associations between ill-health and cognition

Research Interests

My research combines cognitive and neuroimaging methods to answer questions about brain-behaviour associations. My main focus is in age-related conditions and falls into three areas.

Typical Ageing: I examine associations between cognitive decline and changes in the brain with particular reference to cognitive networks and white matter/vascular damage. I am also interested in exploring low mood among older adults and how low mood interacts with cognitive changes in ageing. 

Depression: I use MRI to examine the mechanisms for developing late-life depression and risk for associated cognitive deficits. I am currently working on a project to elevate mood among older adults.

Ageing in Developmental Disorders: Little is known about how individuals with Autism Spectrum Disorders will be affected by age-related brain, cognitive or social changes, I am interested in exploring ageing across developmental disorders.

Publications

Article

Exploratory Study of Executive Function Abilities Across the Adult Lifespan in Individuals Receiving an ASD Diagnosis in Adulthood
Abbott, Patricia; Happe, Francesca and Charlton, Rebecca A. 2018. Exploratory Study of Executive Function Abilities Across the Adult Lifespan in Individuals Receiving an ASD Diagnosis in Adulthood. Journal of Autism and Developmental Disorders, ISSN 0162-3257

Aging with Elevated Autistic Traits: Cognitive Functioning Among Older Adults with the Broad Autism Phenotype
Stewart, GR; Charlton, Rebecca A and Wallace, Gregory L.. 2018. Aging with Elevated Autistic Traits: Cognitive Functioning Among Older Adults with the Broad Autism Phenotype. Research in Autism Spectrum Disorders, 54, pp. 27-36. ISSN 1750-9467)

The efficacy of transcranial random noise stimulation (tRNS) on mood may depend on individual differences including age and trait mood
Evans, Carys; Banissy, Michael J. and Charlton, Rebecca A. 2018. The efficacy of transcranial random noise stimulation (tRNS) on mood may depend on individual differences including age and trait mood. Clinical Neurophysiology, 129(6), pp. 1201-1208. ISSN 1388-2457

Cognitive and affective associations with an ecologically valid test of theory of mind across the lifespan
Johansson Nolaker, E; Murray, K; Happé, Francesca and Charlton, Rebecca A. 2018. Cognitive and affective associations with an ecologically valid test of theory of mind across the lifespan. Neuropsychology, ISSN 0894-4105

Mnemonic function in small vessel disease and associations with white matter tract microstructure
Metoki, A; Brookes, R.L.; Zeestraten, E.; Lawrence, A.J.; Morris, R.G.; Barrick, Thomas R; Markus, Hugh S and Charlton, Rebecca A. 2017. Mnemonic function in small vessel disease and associations with white matter tract microstructure. Neuropsychologia, 104, pp. 1-7. ISSN 0028-3932

Diffusion Tensor Image Segmentation of the Cerebrum Provides a Single Measure of Cerebral Small Vessel Disease Severity Related to Cognition
Williams, O.A.; Zeestraten, E.; Benjamin, P.; Lambert, C.; Lawrence, A.J.; Mackinnon, A.D.; Morris, R G; Markus, Hugh S; Charlton, Rebecca A and Barrick, Thomas R. 2017. Diffusion Tensor Image Segmentation of the Cerebrum Provides a Single Measure of Cerebral Small Vessel Disease Severity Related to Cognition. Neuroimage: Clinical, 16, pp. 330-342.

Divergent Influences of Cardiovascular Disease Risk Factor Domains on Cognition, Grey and White Matter Morphology
Gonzales, M.M.; Ajilore, Olusola; Charlton, Rebecca A; Cohen, J.; Yang, Shaolin; Sieg, E.; Bhaumik, Dulal K.; Kumar, Anand and Lamar, Melissa. 2017. Divergent Influences of Cardiovascular Disease Risk Factor Domains on Cognition, Grey and White Matter Morphology. Psychosomatic Medicine, 79(5), pp. 541-548. ISSN 0033-3174

Aging and Autism Spectrum Disorder: Evidence from the Broad Autism Phenotype
Wallace, Gregory L.; Budgett, Jessica and Charlton, Rebecca A. 2016. Aging and Autism Spectrum Disorder: Evidence from the Broad Autism Phenotype. Autism Research, 9(12), pp. 1294-1303. ISSN 1939-3792

Demographic and cognitive profile of individuals seeking a diagnosis of Autism Spectrum Disorder in adulthood
Happé, Francesca G.E.; Mansour, Hassan; Barrett, Pippa; Brown, Tony; Abbott, Patricia and Charlton, Rebecca A. 2016. Demographic and cognitive profile of individuals seeking a diagnosis of Autism Spectrum Disorder in adulthood. Journal of Autism and Developmental Disorders, 46(11), pp. 3469-3480. ISSN 0162-3257

Cognitive and connectome properties detectable through individual differences in graphomotor organization
Lamar, Melissa; Ajilore, Olusola; Leow, Alex; Charlton, Rebecca A; Cohen, Jamie; GadElkarim, Johnson; Yang, Shaolin; Zhang, Aifeng; Davis, Randall; Penney, Dana; Libon, David J and Kumar, Anand. 2016. Cognitive and connectome properties detectable through individual differences in graphomotor organization. Neuropsychologia, 85, pp. 301-309. ISSN 0028-3932

Brain Connectivity in Late-Life Depression and Aging Revealed by Network Analysis
Charlton, Rebecca A; Leow, Alex; GadElkarim, Johnson; Zhang, Aifeng; Ajilore, Olusola; Yang, Shaolin; Lamar, Melissa and Kumar, Anand. 2015. Brain Connectivity in Late-Life Depression and Aging Revealed by Network Analysis. American Journal of Geriatric Psychiatry, 23(6), pp. 642-650. ISSN 1064-7481

What metabolic syndrome contributes to brain outcomes in African Americans and Caucasian cohorts
Lamar, Melissa; Rubin, Leah; Ajilore, Olusola; Charlton, Rebecca A; Zhang, Aifeng; Yang, Shaolin; Cohen, Jamie and Kumar, Anand. 2015. What metabolic syndrome contributes to brain outcomes in African Americans and Caucasian cohorts. Current Alzheimer Research, 12(7), pp. 640-647. ISSN 1567-2050

Associations between vascular risk and mood in euthymic older adults: Preliminary findings
Charlton, Rebecca A. 2014. Associations between vascular risk and mood in euthymic older adults: Preliminary findings. American Journal of Geriatric Psychiatry, 22(9), pp. 936-945. ISSN 1064-7481

Subcortical Biophysical Abnormalities in Patients with Mood Disorders
Charlton, Rebecca A. 2014. Subcortical Biophysical Abnormalities in Patients with Mood Disorders. Molecular Psychiatry, 19, pp. 710-716. ISSN 1359-4184

White Matter Tract Integrity in Late-Life Depression: Associations with Severity and Cognition
Charlton, Rebecca A. 2014. White Matter Tract Integrity in Late-Life Depression: Associations with Severity and Cognition. Psychological Medicine, 44(7), pp. 1427-1437. ISSN 0033-2917

In Vivo Quantification of White Matter Microstructure for Use in Aging: A Focus on Two Emerging Techniques
Charlton, Rebecca A. 2014. In Vivo Quantification of White Matter Microstructure for Use in Aging: A Focus on Two Emerging Techniques. American Journal of Geriatric Psychiatry, 22(2), pp. 111-121. ISSN 1064-7481

Verbal working and long-term episodic memory associations with white matter microstructure in normal aging investigated using tract-based spatial statistics
Charlton, Rebecca A. 2013. Verbal working and long-term episodic memory associations with white matter microstructure in normal aging investigated using tract-based spatial statistics. Psychology and Aging, 28(3), pp. 768-777. ISSN 0882-7974

Prefrontal vulnerabilities and whole brain connectivity in aging and depression.
Lamar, Melissa; Charlton, Rebecca A; Ajilore, Olusola; Zhang, Aifeng; Yang, Shaolin; Barrick, Thomas R; Rhodes, Emma and Kumar, Anand. 2013. Prefrontal vulnerabilities and whole brain connectivity in aging and depression. Neuropsychologia, pp. 1-6. ISSN 1873-3514

Preliminary analysis of age of illness onset effects on symptom profiles in major depressive disorder.
Charlton, Rebecca A; Lamar, Melissa; Ajilore, Olusola and Kumar, Anand. 2013. Preliminary analysis of age of illness onset effects on symptom profiles in major depressive disorder. International journal of geriatric psychiatry, pp. 1-9. ISSN 1099-1166

Cognitive Dysfunction in Patients Hospitalized with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD).
Dodd, James W; Charlton, Rebecca A; van den Broek, Martin D and Jones, Paul W. 2013. Cognitive Dysfunction in Patients Hospitalized with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Chest, pp. 1-8. ISSN 1931-3543

Brain structure and function in chronic obstructive pulmonary disease: a multimodal cranial magnetic resonance imaging study.
Dodd, James W; Chung, Ai Wern; van den Broek, Martin D; Barrick, Thomas R; Charlton, Rebecca A and Jones, Paul W. 2012. Brain structure and function in chronic obstructive pulmonary disease: a multimodal cranial magnetic resonance imaging study. American journal of respiratory and critical care medicine, 186(3), pp. 240-5. ISSN 1535-4970

Differential associations between types of verbal memory and prefrontal brain structure in healthy aging and late life depression.
Lamar, Melissa; Charlton, Rebecca A; Zhang, Aifeng and Kumar, Anand. 2012. Differential associations between types of verbal memory and prefrontal brain structure in healthy aging and late life depression. Neuropsychologia, 50(8), pp. 1823-9. ISSN 1873-3514

Aging in autism spectrum disorders: a mini-review.
Happé, Francesca and Charlton, Rebecca A. 2012. Aging in autism spectrum disorders: a mini-review. Gerontology, 58(1), pp. 70-8. ISSN 1423-0003

Brain atrophy and cerebral small vessel disease: a prospective follow-up study.
Nitkunan, Arani; Lanfranconi, Silvia; Charlton, Rebecca A; Barrick, Thomas R and Markus, Hugh S. 2011. Brain atrophy and cerebral small vessel disease: a prospective follow-up study. Stroke; a journal of cerebral circulation, 42(1), pp. 133-8. ISSN 1524-4628

Age differences in FMRI adaptation for sound identity and location.
Grady, Cheryl L; Charlton, Rebecca A; He, Yu and Alain, Claude. 2011. Age differences in FMRI adaptation for sound identity and location. Frontiers in human neuroscience, 5, p. 24. ISSN 1662-5161

The impact of subcortical white matter disease on mood in euthymic older adults: a diffusion tensor imaging study.
Lamar, Melissa; Charlton, Rebecca A; Morris, Robin G and Markus, Hugh S. 2010. The impact of subcortical white matter disease on mood in euthymic older adults: a diffusion tensor imaging study. The American Journal of Geriatric Psychiatry, 18(7), pp. 634-42. ISSN 1545-7214

White matter structural decline in normal ageing: a prospective longitudinal study using tract-based spatial statistics.
Barrick, Thomas R; Charlton, Rebecca A; Clark, Chris A and Markus, Hugh S. 2010. White matter structural decline in normal ageing: a prospective longitudinal study using tract-based spatial statistics. NeuroImage, 51(2), pp. 565-77. ISSN 1053-8119

White matter pathways associated with working memory in normal aging.
Charlton, Rebecca A; Barrick, Thomas R; Lawes, I Nigel C; Markus, Hugh S and Morris, Robin G. 2010. White matter pathways associated with working memory in normal aging. Cortex, 46(4), pp. 474-89. ISSN 1973-8102

The relationship between episodic long-term memory and white matter integrity in normal aging.
Charlton, Rebecca A; Barrick, T R; Markus, H S and Morris, R G. 2010. The relationship between episodic long-term memory and white matter integrity in normal aging. Neuropsychologia, 48(1), pp. 114-22. ISSN 1873-3514

Diffusion tensor imaging detects age related white matter change over a 2 year follow-up which is associated with working memory decline.
Charlton, Rebecca A; Schiavone, F; Barrick, T R; Morris, R G and Markus, H S. 2010. Diffusion tensor imaging detects age related white matter change over a 2 year follow-up which is associated with working memory decline. Journal of Neurology, Neurosurgery, and Psychiatry, 81(1), pp. 13-19. ISSN 0022-3050

Theory of mind associations with other cognitive functions and brain imaging in normal aging.
Charlton, Rebecca A; Barrick, Thomas R; Markus, Hugh S and Morris, Robin G. 2009. Theory of mind associations with other cognitive functions and brain imaging in normal aging. Psychology and aging, 24(2), pp. 338-48. ISSN 0882-7974

Cognitive impairment and white matter damage in hypertension: a pilot study.
Hannesdottir, K; Nitkunan, A; Charlton, Rebecca A; Barrick, T R; MacGregor, G A and Markus, H S. 2009. Cognitive impairment and white matter damage in hypertension: a pilot study. Acta neurologica Scandinavica, 119(4), pp. 261-8. ISSN 1600-0404

Reduced N-acetylaspartate is consistent with axonal dysfunction in cerebral small vessel disease.
Nitkunan, Arani; Charlton, Rebecca A; Barrick, Thomas R; McIntyre, Dominick J O; Howe, Franklyn A and Markus, Hugh S. 2009. Reduced N-acetylaspartate is consistent with axonal dysfunction in cerebral small vessel disease. NMR in biomedicine, 22(3), pp. 285-91. ISSN 0952-3480

Imaging age-related cognitive decline: A comparison of diffusion tensor and magnetization transfer MRI.
Schiavone, Francesca; Charlton, Rebecca A; Barrick, Thomas Richard; Morris, Robin Guy and Markus, Hugh Stephen. 2009. Imaging age-related cognitive decline: A comparison of diffusion tensor and magnetization transfer MRI. Journal of magnetic resonance imaging : JMRI, 29(1), pp. 23-30. ISSN 1053-1807

A structural equation modeling investigation of age-related variance in executive function and DTI measured white matter damage.
Charlton, Rebecca A; Landau, S; Schiavone, F; Barrick, T R; Clark, C A; Markus, H S and Morris, R G. 2008. A structural equation modeling investigation of age-related variance in executive function and DTI measured white matter damage. Neurobiology of aging, 29(10), pp. 1547-55. ISSN 1558-1497

Multimodal MRI in cerebral small vessel disease: its relationship with cognition and sensitivity to change over time.
Nitkunan, Arani; Barrick, Tom R; Charlton, Rebecca A; Clark, Chris A and Markus, Hugh S. 2008. Multimodal MRI in cerebral small vessel disease: its relationship with cognition and sensitivity to change over time. Stroke; a journal of cerebral circulation, 39(7), pp. 1999-2005. ISSN 1524-4628

Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease.
Nitkunan, Arani; Charlton, Rebecca A; McIntyre, Dominick J O; Barrick, Thomas R; Howe, Franklyn A and Markus, Hugh S. 2008. Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 59(3), pp. 528-34. ISSN 0740-3194

Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain.
McIntyre, Dominick J O; Charlton, Rebecca A; Markus, Hugh S and Howe, Franklyn A. 2007. Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain. Journal of magnetic resonance imaging : JMRI, 26(6), pp. 1596-606. ISSN 1053-1807

The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study.
Charlton, Rebecca A; McIntyre, D J O; Howe, F A; Morris, R G and Markus, H S. 2007. The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study. Brain research, 1164, pp. 108-16. ISSN 0006-8993

Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages.
Happé, Francesca; Booth, Rhonda; Charlton, Rebecca A and Hughes, Claire. 2006. Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages. Brain and cognition, 61(1), pp. 25-39. ISSN 0278-2626

The cognitive profiles of CADASIL and sporadic small vessel disease.
Charlton, Rebecca A; Morris, R G; Nitkunan, A and Markus, H S. 2006. The cognitive profiles of CADASIL and sporadic small vessel disease. Neurology, 66(10), pp. 1523-6. ISSN 1526-632X

White matter damage on diffusion tensor imaging correlates with age-related cognitive decline.
Charlton, Rebecca A; Barrick, T R; McIntyre, D J; Shen, Y; O'Sullivan, M; Howe, F A; Clark, C A; Morris, R G and Markus, H S. 2006. White matter damage on diffusion tensor imaging correlates with age-related cognitive decline. Neurology, 66(2), pp. 217-22. ISSN 1526-632X

Diffusion tensor imaging of thalamus correlates with cognition in CADASIL without dementia.
O'Sullivan, Michael; Singhal, Sumeet; Charlton, Rebecca A and Markus, Hugh S. 2004. Diffusion tensor imaging of thalamus correlates with cognition in CADASIL without dementia. Neurology, 62(5), pp. 702-7. ISSN 1526-632X

Disentangling weak coherence and executive dysfunction: planning drawing in autism and attention-deficit/hyperactivity disorder.
Booth, Rhonda; Charlton, Rebecca A; Hughes, Claire and Happé, Francesca. 2003. Disentangling weak coherence and executive dysfunction: planning drawing in autism and attention-deficit/hyperactivity disorder. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 358(1430), pp. 387-92. ISSN 0962-8436

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